Generic Floxin

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Manufacturer: Aristopharma Ltd., Ranbaxy Laboratories Ltd.
Floxin is an antimicrobial broad-spectrum drug from the group fluoroquinolones. Acts on the bacterial enzyme DNA girazu providing sverzellati and, thus, the stability of the DNA of bacteria (destabilization of the DNA strands leads to their death). Floxin has a bactericidal effect.

Like other fluoroquinolones, Ofloxacin has a broad antibacterial spectrum of action. Has affection predominantly to gram-negative bacteria. Ofloxacin is effective against microorganisms resistant to most antibiotics and sulfanilamidam. Floxin has bactericidal (destroys bacteria) effect. Ofloxacin is effective when taken orally. Rapidly and almost completely (over 95%) absorbed from the gastrointestinal tract, comes in high concentrations in organs and tissues, as well as in sputum, saliva, bile, skin, tissue and prostatic secretions. Peak concentrations in plasma observed after 30-60 min.

Floxin is active against organisms producing β-lactamase and fast-growing atypical mycobacteria.

Bacteria sensitive to the Ofloxacin: Staphylococcus aureus, Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Hafnia spp. Proteus spp. (including Proteus mirabilis, Proteus vulgaris is indole-positive and indole-negative strains), Shigella spp. (including Shigella sonnei), Yersinia enterocolitica, Salmonella spp., Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas aeruginosa, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp., Legionella spp. Serratia spp. Providencia spp. Haemophilus ducreyi, Bordetella parapertussis, Bordetella pertussis, Moraxella catarrhalis, Propionibacterium acnes, Brucella spp.

Different sensitivity to the Ofloxacin have: Streptococcus pneumoniae, Enterococcus faecalis, Serrratia marcescens, Mycoplasma hominis, Pseudomonas aeruginosa, Streptococcus pyogenes, Acinetobacter spp., Ureaplasma urealyticum, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Streptococcus viridans, Mycobacteriurn fortuitum, Gardnerella vaginalis, Clostridium perfringens, Corynebacterium spp., Helicobacter pylori, Listeria monocytogenes.

To Ofloxacin resistant Nocardia asteroides, anaerobic bacteria (Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacterium spp., Fusobacterium spp., Clostridium difficile).

Floxin is inactive against Treponema pallidum.

Ofloxacin is used for treat infections of the respiratory tract, ear, throat, nose, skin, soft tissues, osteomyelitis (inflammation of bone marrow and adjacent bone), infectious diseases of abdominal cavity organs, kidneys, mochevyvodyashih ways, prostatitis (inflammation of prostate), gynecological infectious diseases, gonorrhea. There is evidence of activity of Ofloxacin against Mycobacterium tuberculosis and the feasibility of its application in complex therapy of tuberculosis.

Indications: infectious-inflammatory diseases of the respiratory tract (bronchitis, pneumonia), infectious-inflammatory diseases of ENT-organs (sinusitis, pharyngitis, otitis media, laryngitis), infectious-inflammatory diseases of the skin and soft tissues, infection and inflammatory disease of bones and joints, infectious-inflammatory diseases of the abdominal cavity (including infection GI) tract and bile ducts, infectious-inflammatory diseases of the kidneys (pyelonephritis) and urinary tract (cystitis, urethritis), infection-inflammatory diseases of the pelvic organs (endometritis, salpingitis, oophoritis, cervicitis, parametritis, prostatitis) and genital organs (colpitis, orchitis, epididymitis), gonorrhea, chlamydia, meningitis, prevention of infections in patients with impaired immune status (including with neutropenia).

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